Anabolic steroids are synthec derivaves of testosterone. Oxymetholone enhances the producon and urinary excreon of erythropoien in paents with anemias due to bone marrow failure and oen smulates erythropoiesis in anemias due to deficient red cell producon. The acons of aaabolic steroids are similar to those of male sex hormones with the possibility of causing serious disturbances of growth and sexual development if given to young children. They suppress the gonadotropic funcons of the pituitary and may exert a direct effect upon the testes.

INDICATIONS AND USAGE:

oxymetholone Tablet is indicated in the treatment of anemias caused by deficient red cell producon. Acquired a plasc anemia, congenital aplasc anemia, myelofibrosis and the hypoplasc anemias due to the administraon of myelotoxic drugs oen respond.oxymetholone Tablets should not replace other supporve measures such as transfusion, correcon of iron, folic acid, vitamin B₁₂ or pyridoxine deficiency, anbacterial therapy and the appropriate use of corcosteroids.

DOSAGE AND ADMINISTRATION:

The recommended daily dose in children and adults is 1-5 mg/kg body weight per day. The usual effecve dose is 1-2 mg/kg/day but higher doses may be required, and the dose should be individualized: Response is not oen immediate, and a minimum trial of three to six months should be given. Following remission, some paents may be maintained without the drug; others may be maintained on an established lower daily dosage. A connued maintenance dose is usually necessary in paents with congenital aplasc anemia.